A relation between metabolic syndrome (MS) and lung diseases has been observed in
several cross-sectional and longitudinal studies. This syndrome has been identified as an independent risk
factor for worsening respiratory symptoms and much more lung function impairment.
Aim: was to study the effect of metabolic syndrome on ventilatory pulmonary functions.
Subjects and methods: This study included 60 subjects. They were further divided to two groups, group
(A) included 45 patients with metabolic syndrome and group (B) included 15 apparently healthy subjects
as a control group. All were subjected to the followings:History taking and physical examination (Blood
pressure, BMI and waist circumference), laboratory investigations as FBG, lipid profiles (TG and HDL),
CRP and HbA1C and spirometry (FVC, FEV1and FEV1/FVC).
Results:Among metabolic syndrome subjects (n=45), 28 (63%) had restrictive ventilatory pattern, 3 (6%)
had obstructive pattern, 9 (20%) were normal, while 5 (11%) had mixed pattern. Pulmonary functions
were impaired more among metabolic syndrome cases. FVC% predicted of group (A) was 61.49 %±17.56
while for group (B) was 85.73%±5.24. FEV1 % predicted of group (A) was 66.22%±18.7 while for group
(B) was 87.73%±7.98 and differences were statistically highly significant.Pulmonaryfunctions impairment
was more prominent among males than females.After examining the association between metabolic
components and both FVC % predicted and FEV1 % predicted, results revealed that there was a strong
linear decrease in FVC % predicted and FEV1 % predicted as the number of components of metabolic
syndrome increased. The β coefficients of FVC % predicted for those with 1, 2, 3, 4 and 5 features of
metabolic syndrome were 0.011,-0.018, -0.023, -0.035 and -0.048 in men and 0.020, -0.029, -0.035, -
0.047 and -0.068 in women respectively. The β coefficients of FEV1 % predicted for those with 1, 2, 3, 4
and 5 features of metabolic syndrome were 0.009, -0.015, -0.026, -0.041and -0.051 in males and 0.004, -
0.009, -0.017, -0.029 and- 0.038 in females, respectively.
Conclusion:Pulmonary function impairment (mainly restrictive pattern) is commonly associated with
metabolic syndrome. Forced vital capacity and forced expiratory volume in the first second are associated
inversely with the accumulation of elements of the metabolic syndrome and is also associated
independently with each element of the metabolic syndrome especially waist circumference. |
