Background: Diabetic neuropathy, a serious microvascular
consequence of diabetes mellitus (DM), affects up to 50% of those
with type 1 and type 2 DM. It is the most typical DM complication. A
person with diabetes is stated to have diabetic peripheral neuropathy
once all other potential causes of peripheral nerve damage have been
ruled out. This study's objective was to measure the serum sialic acid
concentration in patients with type 2 DM and to assess if it could be
used as an early marker of diabetic neuropathy Methods: This was a
cross sectional study that was carried out on 40 patients subdivided
into 3 groups. The first group involved 25 patients with diabetic
neuropathy, second group involved 15 patients without diabetic
neuropathy and the third group involved 10 healthy patients serving as
a control group. All patients were selected from those attending the
outpatient diabetic clinic at Benha University Hospital between July
2017 and July 2018. Results: when comparing diabetic neuropathy
patients to the control group of individuals, it was discovered that the
serum sialic level was higher in diabetic patients with neuropathy than
in diabetic patients without neuropathy. The age of diabetes diagnosis
or the duration of diabetes were not related to serum sialic acid levels.
Conclusions: serum sialic acid level is significantly increased in
patients with diabetic neuropathy, and it is positively correlated with
the glycemic control parameters |
