You are in:Home/Publications/WEIGHT REDUCTION AMELIORATES THE INHIBITORY EFFECTS OF OBESITY AND INSULIN RESISTANCE ON OVARIAN FUNCTION IN PCOS WOMEN

Prof. Ayman ahmed abd elhamid shdid :: Publications:

Title:
WEIGHT REDUCTION AMELIORATES THE INHIBITORY EFFECTS OF OBESITY AND INSULIN RESISTANCE ON OVARIAN FUNCTION IN PCOS WOMEN
Authors: Ahmed Walid Anwar Morad1, Ayman Ahmed Abdelhamid1 and Safaa Ibrahiem Abbas2
Year: 2011
Keywords: Polycystic ovary syndrome, weight reduction, clomiphene citrate, ovulation.
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Ayman ahmed abd elhamid shdid_WEIGHT_REDUCTION_AMELIORATES_THE_INHIBITORY_EFFECTS_OF_OBESITY_AND_INSULIN_RESISTANCE_ON_OVARIAN_FUNCTION_IN_PCOS_WOMEN-libre.pdf
Supplementary materials Not Available
Abstract:

Objectives: To evaluate the impact of weight reduction and changes in lifestyle compared to insulin sensitizers used alone or in combination with lifestyle changes on the ovulatory function of polycystic ovary syndrome (PCOS) women Patients & Methods: Ninety clomiphene citrate (CC) resistant PCOS women were randomly allocated into three equal groups: Group A received oral CC 50 mg twice daily on Days 2–6 of a menstrual period and metformin oral 0.5 gm tablets trice daily, Group B assigned to undergo dieting regimen and changing lifestyle towards increased energy expenditure and received no medications and Group C assigned to undergo dieting regimen in conjunction with metformin/CC combination treatment. All patients underwent transvaginal ultrasonographic examination and body height and weight measurements and calculation of body mass index (BMI). Fasting blood glucose (FBG), fasting plasma insulin (FPI) levels were estimated and hormone profile was obtained. Insulin resistance (IR) was measured using Matthews homeostasis model assessment (HOMA) with the HOMA-IR score >2 was considered as insulin resistant. At end of 3 months, BMI and HOMA-IR scores were re-evaluated and ovulation was considered the primary outcome and reduction of BMI and HOMA-IR scores as secondary outcome. Results: Sixty-three women got ovulation with ovulatory success rate of 86.7% in group C, 76.7% in group A and 46.7% in group B with significantly higher ovulatory success rate in groups A and C compared to group B and non-significantly higher rate in group C compared to group A. All applied therapeutic strategies effectively reduced body weight and BMI with significant reduction of BMI grades in association with significant reduction of FBG and FPI levels and significant reduction of HOMA-IR score and number of women with IR score>2. These effects were marvelous in group C with superior outcome followed by group B and lastly group A Conclusion: Obesity and insulin resistance have inhibitory effect on ovarian function and reproductive life of PCOS women and combined pharmacotherapy and weight reduction regimens associated with changes in lifestyle towards increased energy expenditure induces weight loss and improves insulin sensitivity with subsequent induction of ovulation

Google ScholarAcdemia.eduResearch GateLinkedinFacebookTwitterGoogle PlusYoutubeWordpressInstagramMendeleyZoteroEvernoteORCIDScopus