The efficacy of Zingiber officinale extract (ZOE) against toxocariasis was investigated in experimental mice and results were compared to those obtained using albendazole and combination of albendazole and Zingiber officinale extract(Albz) .Sixty male albino mice, 10 weeks-old, were classified into 6 experimental groups of 10 mice each:
Group I: None infected non-treated (normal control) and received 0.1 ml of sterile distilled water. Group II: Infected mice with T. canis eggs (infected control). Group III: Infected mice by treated eggs with ZOE (T. canis eggs were incubated 24h with 500 mg/ml of ZOE before mice inoculation. Group IV: Infected mice by T. canis eggs and treated by albendazole (drug control).Group V: Infected mice by T .canis eggs and treated by ZOE. Group VI: Infected mice by T .canis eggs and treated by combination of albendazole and ZOE.The present study showed that, Zingiber officinale extract (ZOE) had a significant inhibitory effect on the larval recovery rates in the brain and eye compared to the infected and drug controls. Combination of albendazole and Zingiber officinale extract (Albz) reduced the larval counts by higher percentages attaining the best results.The most obvious reduction in larval counts was observed in GVI to be 94.50% and 96.34% respectively. It was observed that the larvae in all treated groups showed sluggish movement Zingiber officinale improved the induced pathological changes by Toxocara in the studied organs that regressed to near normal picture. .Zingiber officinale seemed to be effective as albendazole against T. canis infection. However, a greater effect was obtained by their combination. |
