Abstract---Objective: To determine whether peripheral natural killer
(NK) cells play a role in recurrent miscarriage by evaluating the
percentage of these cells using flow cytometry and comparing it with
the percentages in normal multiparous women and women who
experienced miscarriage only once. Methods: This case-control study
was carried out on a total of 108 women. The study participants
consisted of two groups of cases: unexplained recurrent miscarriage
cases (n=36) and explained recurrent miscarriage cases (n=36).
Additionally, a control group of normal multiparous women or women
with only one previous miscarriage (n=36) was included. Detailed
clinical assessments, laboratory investigations, and flow cytometry
analysis were conducted to collect relevant data. Flow cytometry was
used to determine the percentage of CD56+ NK cells in peripheral
blood samples. Results: The mean age of the participants ranged from
26.72 to 28.33 years, with no significant difference among the three
groups. Parity showed a statistically significant difference, with a
higher proportion of nulliparous women in the unexplained abortion
group. The number of previous abortions did not differ significantly
between the unexplained and explained groups. Among the causes of
abortion, endocrine and immunological factors were prominent. NK%
CD56 levels were significantly higher in both the unexplained and
explained abortion groups compared to the control group. |
