ABSTRACT
Background: Helicobacter pylori (H. pylori) infection is the most common infection in the world and
coronary artery disease (CAD) is probably associated with it.
Aim: The aim of this prospective study was to evaluate the association between H. pylori infection
and other risk factors with suspected CAD patients and to investigate the influence of H. pylori
infection on cardiovascular risk factors (lipid profile and. Highly sensitive C-reactive protein (hs
CRP) levels).
Methods: Prospective cross sectional study was conducted to involve one hundred twenty patients
with dyspeptic symptoms who involved 60 patients suffering from CAD and 60 controls who
attended the gastrointestinal endoscopy clinic of the departments of internal medicine in ALQuwayiyah
General Hospital, Riadh, KSA. The study was carried out for six months from June to -
November 2015. H. pylori were detected by rapid urease test, H. pylori IgG ELISA test andhistopathology. Total cholesterol (TC), high density lipoprotein cholesterol (HDL- c) and
triglycerides (TG) were measured by enzymatic methods using an automated chemistry analyzer.
Low density lipoprotein cholesterol (LDL- c) was calculated using the Friedewald equation. hs CRP
levels were estimated.
Results: H. pylori was confirmed in 80 (66.7%) of total 120 patients and controls by histology (gold
method for diagnosis) and 80 (66.7%) by rapid urease test while 75 (62.5%) was detected by
serology. There was no significant difference in age, sex or coronary artery risk factors between the
two groups, but the prevalence of infectivity for H. pylori was higher in patients compared to
controls (47{78.3%} versus 33 {55%} P |
