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Dr. Badawy Abdel- Khalik Abdel - Aziz :: Publications:

Title:
Vitamin D-Binding Protein as a Diagnostic Biomarker for Acute Meningitis
Authors: Badawy A. AbdulAziz1 , Magdy Abdul Mawgoud Gad1 , Mahmoud Ali Khalil2 , Lamyaa Mohmed Kamal3 , Mohamed Ahmed AbdelMonem1
Year: 2023
Keywords: Cerebrospinal fluid, Vitamin D-binding protein, Meningitis Biomarker
Journal: The Egyptian Journal of Hospital Medicine
Volume: 92
Issue: Not Available
Pages: 6387- 6394
Publisher: Ain Shams University, Faculty of Medicine
Local/International: International
Paper Link:
Full paper Badawy Abdel- Khalik Abdel - Aziz_paper 6.pdf
Supplementary materials Not Available
Abstract:

Background Meningitis is an acute inflammation of the pia, arachnoids, and the fluid in the subarachnoid space of the brain. Because there is no diagnostic biomarker, it is difficult to diagnose. Objective: The aim of the current study was to evaluate the validity of using cerebrospinal fluid (CSF) Vitamin-D Binding Protein (VDBP) as a new potential marker for diagnosing meningitis. Patients and methods: A cross-section study was conducted on 48 patients with manifestations suggesting an acute meningitis, 28 patients with an acute meningitis who were divided into bacterial group containing 10 patients and viral group containing 18 patients confirmed by laboratory investigations and 20 patients who were clinically suspected as an acute meningitis, but excluded by laboratory investigations, the study was conducted within the period from May 2022 to December 2022. CSF and blood samples were obtained in pairs. CSF and serum VDBP were measured in the 3 groups. CSF VDBP concentrations were compared versus serum VDBP concentrations according to disease (viral meningitis vs. bacterial meningitis vs non-meningitis). Receiver operating characteristic (ROC) analysis for diagnosing meningitis using CSF VDBP concentration was performed. Results: There was a statistical significant difference as regard the CSF VDBP (P

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