Objectives: Estimation of serum Kisspeptin-l (Kiss-I)
and beta human chorionic gonadotropin (ßhCG) levels at
time ofpregnancy diagnosis (Booking time) and at the
12th gestational week; Sl and S2 samples, in trial to
evaluate the predictability of these levels for the
possibility of early pregnancy loss (EPL).
Patients & Methods: 283 women gave S2 samples, 76
women (26.9%) developed EPL (EPL group) and 207
women had viable fetus (Control group). Blood samples
were obtamed for ELISA estimation of serum Kiss-I and
ßhCG. The study outcome was the predictability of Sl
levels of both parameters for the possibility of oncoming
pregnancy loss.
Results: Sl sample ßhCG levels showed non-significant
differences between both groups, while serum Kiss-I
levels were significantly lower in EPL than in control
women. Serum levels of both parameters in S2 sample
were signifi cantly lower m EPL than both control
women and levels estimated in Sl samples of EPL
women. Incidence ofEPL was negatively correlated with
Sl sample serum levels of both parameters. Regression
analysis defined 6500 IU/L and 318 pmol/L as cutoff
points for ßhCG and Kiss-I to predict 50% hazard for
EPL. These cutoff points defined 158 and 181 tme cases,
respectively with significant difference m favor of Kiss-I
value. ROC curve analysis assured the sensitivity of
lower Sl levels of both pammeters for prediction of 50%
hazard ofEPL, but area difference under ROC was
significant in favor of low serum Kiss-I as a significant
sensitive predictor for EPL.
Conclusion: Estimation of serum kiss-I at time of
pregnancy diagnosis inversely correlates with incidence
of EPL. Lower serum Kiss-I levels had significantly
higher predictability for EPL than ßhCG. Lower serum
Kiss-I at the 12th GW or development of EPL assured
the predictability of the result obtained at booking time
and spared the need for sequential estimations |
