Background/aim
The exact cause of systemic lupus erythematosus (SLE), an autoimmune disorder,
is still vague. However, it is believed that its pathogenesis could be a result of the
interplay between genetics and the environment. One such genetic factor is a
single-nucleotide polymorphism in the CD11b gene (rs1143679) that has been
shown to potentially increase a person’s susceptibility to SLE. This study aims to
investigate the possible link of CD11b rs1143679 gene polymorphism to the risk of
developing SLE, as well as the different manifestations and the disease severity in
the studied group of Egyptian SLE patients.
Patients and methods
The present study enrolled 50 patients with SLE from Benha University Hospitals,
Egypt. In addition to 30 apparently healthy individuals served as control, the CD11b
gene (rs1143679) genetic variant was investigated by real-time PCR. The
individuals with SLE were based on the Systemic Lupus International
Collaborating Clinics criteria.
Results
A significant association of GA genotype (odds ratio=1.908, 95% confidence
interval=1.021–3.568, P |
