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Prof. Deena A Elshabrawy :: Publications: |
Title: | EphB2 isolates a human marrow stromal cell subpopulation with enhanced ability to contribute to the resident intestinal cellular pool |
Authors: | Evan Colletti,* Deena El Shabrawy,*,1 Melisa Soland,*‖ Takashi Yamagami,*,2 Saloomeh Mokhtari,*‖ Craig Osborne,† Karen Schlauch,‡§ Esmail D. Zanjani,* Christopher D. Porada,*‖ and Graça Almeida-Porada*‖, |
Year: | 2013 |
Keywords: | crypts of Lieberkühn, transcriptome, Musashi-1, epithelial, Lgr5, transplant, niche |
Journal: | Not Available |
Volume: | Not Available |
Issue: | Not Available |
Pages: | Not Available |
Publisher: | Not Available |
Local/International: | International |
Paper Link: | Not Available |
Full paper | Not Available |
Supplementary materials | Not Available |
Abstract: |
To identify human bone marrow stromal cell (BMSC) subsets with enhanced ability to engraft/contribute to the resident intestinal cellular pool, we transplanted clonally derived BMSCs into fetal sheep. Analysis at 75 d post-transplantation showed 2 of the 6 clones engrafting the intestine at 4- to 5-fold higher levels (5.03±0.089 and 5.04±0.15%, respectively) than the other clones (P |