Summary
Background: Acne is an inflammatory skin condition of pilosebaceous unit. Its
pathogenesis is multifactorial with a central role of inflammatory and pro inflammatory
cytokines mediators. Downregulated Kruppel like factor 2 (KLF2) leads to rapid secretion of
many cytokines that are involved in acne pathogenesis.
Aims: This study aimed at evaluating the level of KLF2 mRNA, clarifying its role in acne
pathogenesis and its relation to acne lesion type, degree of severity and outcome.
Patients and Methods: The level of KLF2 mRNA was measured in 100 patients with
acne and 50 age and sex matched healthy controls by using quantitative real-time polymerase
chain reaction (qRT-PCR).
Results: The value of KLF2 mRNA was lower in acne patients than control group (P
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