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Dr. marwa abdullah elsayed abdelwahed :: Publications:

Title:
Serum uric acid level in patients with cerebrovascular ischemic stroke: relation to initial stroke severity and outcome.
Authors: Marwa Abdallah Dawood, Abo Zaid Abdallah Khodair, Maged Kamal Faheem and Shaimaa Mohammed Kasem
Year: 2016
Keywords: Serum uric acid, acute cerebrovascular ischemic stroke
Journal: Nature and Science
Volume: 14
Issue: 2
Pages: 32-40
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper marwa abdullah elsayed abdelwahed_paper nature.pdf
Supplementary materials Not Available
Abstract:

Background: Ischemic stroke remains a major health care problem and a leading cause of morbidity and mortality. The role of serum uric acid (SUA) in cerebrovascular ischemic stroke (CVIS) is controversial. It is unclear whether it promotes or protects against the cerebrovascular disease or simply acts as a passive marker of increased risk. Aim of the study: to detect SUA level in acute CVIS patients and to investigate the relationship between it and stroke severity, outcome, and infarction size. Methods and Results: In this case control study, forty CVIS patients (26 males & 14 females) and twenty age matched control subjects were recruited for this study. Serum uric acid was estimated by Uricase method. Assessment of severity of stroke was done based on Canadian Neurological Scale. Assessment of outcome on discharge was done based on Barthel index score. In this study serum uric acid levels were raised in stroke cases when compared to controls on admission. The mean and standard deviation of uric acid were 7.5±2.15 in cases and 4.25±0.88 in controls with significant p value of < 0.001. Cases with high uric acid levels had low severity and outcome scores which indicate poor prognosis. Mean value of SUA level in 4 patients who died was significantly higher than other patients who survived with significant p value of < 0.001. Mean SUA level was higher among patients with large infarction size (mean value: 8.76 mg/dL). Conclusion: Elevated levels of serum uric acid can be used as one of the factors that predicts poor prognosis of ischemic stroke.

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