Patients with end-stage renal disease (ESRD) often develop various health
complications, including pulmonary dysfunction. Hemodialysis (HD) is a common
treatment for these patients, but its effects on pulmonary function remain an
area of investigation. This study aimed to assess the impact of HD on spirometry
parameters in ESRD patients.
Patients and methods
This prospective study was carried out on 60 patients with ESRD on HD. Spirometry
parameters, including vital capacity (VC), forced vital capacity (FVC), forced
expiratory volume in the first second (FEV1), FEV1/FVC ratio, peak expiratory flow
(PEF), and forced expiratory flow between 25 and 75% of FVC (FEF 25–75%),
were measured 1 h before and after HD.
Results
After HD, significant improvements were observed in several spirometry
parameters. The median % change in VC was 9.92% (range, −27.05 to 47.66%),
in FVC% was 11.68% (range, −16.5 to 47.37%), in FEV1% was 12.56% (range,
−2 to 49.43%), in FEV1/FVC was 1.52% (range, −9.39 to 17.32%), in PEF% was
14.86% (range, −15.33 to 131.73%), and in FEF 25–75% was 13.89% (range,
−14.29 to 97.56%).
Conclusions
In ESRD patients, pulmonary abnormalities, primarily restrictive and mixed
disorders, were common. Spirometry parameters (FVC, FEV1, PEF rate) were
often below normal. However, HD led to notable improvements in VC, FVC, FEV1,
FEV1/FVC, FEF 25–75%, PEF rate, and arterial blood gases parameters (pH,
CO2, HCO3, SO2). |
