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Prof. Ebada Mohamed Said Abd El Hameed :: Publications:

Assessment of Liver Fibrosis in Egyptian Chronic Hepatitis B Patients: A Comparative Study Including 5 Noninvasive Indexes
Authors: Mohammed Tag-Adeen, MD, PhDa,∗, Maha Zeinelabedin Omar, MD, PhDb, Fatma Mohamed Abd-Elsalam, MD, PhDb, Ali Hasaneen, MD, PhDc, Mohamed Ahmed Mohamed, MD, PhDc, Hala Mohamed Elfeky, MD, PhDb, Ebada Mohamed Said, MD, PhDb, Badawy Abdul-Aziz, MD, PhDb, Amir
Year: 2018
Keywords: AAR, APRI, chronic hepatitis B, Fib-4, noninvasive indexes, RPR, S-index.
Journal: Medicine
Volume: 6
Issue: Not Available
Pages: 97
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Ebada Mohamed Said Abd El Hameed_2.pdf
Supplementary materials Not Available

Fibrosis assessment in chronic hepatitis B (CHB) is essential for prediction of long-term prognosis and proper treatment decision. This study was conducted to assess predictability of 5 simple noninvasive fibrosis indexes in comparison to liver biopsy in CHB patients. A total of 200 CHB adult Egyptian patients were consecutively included in this study, all were subjected to liver biopsy with staging of fibrosis using METAVIR scoring system. Fibrosis indexes including S-index, red cell distribution width to platelets ratio index (RPR), fibrosis-4 index (Fib-4), AST to platelets ratio index (APRI), and AST/ALT ratio index (AAR) were compared to biopsy result and their predictabilities for the different fibrosis stages were assessed using area under receiver operating characteristic curve (AUROC) analysis. S-index showed the highest AUROCs for predicting fibrosis among the studied indexes. AUROCs of S-index, RPR, Fib-4, APRI, and AAR were: 0.81, 0.67, 0.70, 0.68, and 0.60 for prediction of significant fibrosis (F2–F4), 0.90, 0.66, 0.68, 0.67, and 0.57 for advanced fibrosis (F3–F4), and 0.96, 0.62, 0.61, 0.57, and 0.53 for cirrhosis (F4), respectively. The optimal S-index cutoff for ruling in significant fibrosis was ≥0.3 with 94% specificity, 87% PPV, and 68% accuracy, while that for ruling out significant fibrosis was

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