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Assist. Ebtssam Gamal Ahmed Beder :: Publications: |
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| Title: | Mito-TEMPO, A Selective Mitochondrial Antioxidant Alleviates
Acrylamide-Mediated Anterior 2/3 Lingual Damage in Rats.
Biochemical, Histological and Immunohistochemical Study
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| Authors: | Heba Bayoumi1, Enas Elgendy1, Hala Taha Shalan2, Ebtssam Beder3, Nashwa Elsayed4 and Amira Elalfy1 |
| Year: | 2024 |
| Keywords: | Not Available |
| Journal: | Egyptian Journal of Histology |
| Volume: | 47 |
| Issue: | 2 |
| Pages: | Not Available |
| Publisher: | Not Available |
| Local/International: | Local |
| Paper Link: | Not Available |
| Full paper | Ebtssam Gamal Ahmed Beder_EJH_Volume 47_Issue 2_Pages 706-724 (4).pdf |
| Supplementary materials | Not Available |
| Abstract: |
Background: Acrylamide (ACR) is a common toxicant. One of the most critical worldwide health issues right now is the exposure of individuals and animals to ACR through their diet. Dietary antioxidants have received attention as potential preventive strategy and as a nutritional supplement for addressing various ACR-induced toxicities. Aim of work: Studying the potential protective effect of Mito-TEMPO (MT) a selective mitochondrial antioxidant on acrylamide induced lingual toxicity. Study design: Thirty two adult male rats were separated into 3 sets. Group I (control group). Group II (ACR group): Rats were treated with 40 mg/kg/d acrylamide that was dissolved in physiological saline and given orally by gavage for 14 days. Group III (ACR+ MT group): Rats were treated as group II and were injected with 0.7 mg/kg of Mito-TEMPO (ip) once/day for 2 days before acrylamide and continued with acrylamide for another 14 days. It was given 30 minutes before acrylamide. Results: Acrylamide intoxicated group revealed significant decline (P |
