Objective: To evaluate the efficacy and safety of a single intra detrusor injection of
BoNTA comparing two different doses (100 U or 200 U) in patients with idiopathic
overactive bladder.
Materials and Methods: A randomized prospective study evaluated the efficacy of
BoNTA in management of refractory idiopathic overactive bladder and included 80 patients.
All patients were assessed initially by taking a history, a physical examination,
overactive bladder symptom score, urine analysis, routine laboratory investigations,
KUB and pelviabdominal. OABSS was adjusted on all patients postoperative at 1,3,6,9
months also Urodynamic was done for all patients preoperative and postoperative at
3, 6, 9 months.
Results: The mean age was 30.22±8.37 and 31.35±7.61 in group I and II respectively.
There was no statistically difference between both groups in all parameters all over the
study except at 9 months after treatment. Hematuria was observed 6 and 9 patients in
group I and II respectively. Dysuria was observed in 6 and 15 patients in group I and II
respectively. UTI was detected in 3 and 7 patients in group I and II respectively.
Conclusion: A single-injection procedure of 100 U or 200 U BoNTA is an effective and
safe treatment for patients with IOAB who failed anticholinergic regimens. OABSS and
QoL were improved for 6 months; 100 U injections seemed to have comparable results
with 200 U. There was a significant difference at month 9 towards 200 U with more
incidences of adverse events. |
