Background: Dual trigger for final oocyte maturation using combination of GnRha and hCG can improve clinical outcomes in high responder IVF-ICSI GnRh antagonist protocol. However this modality is not widely studied in normal responder.
Aim of the work; to investigate whether “dual triggering”, combination of GnRha and hCG for final oocyte maturation, improve the live-birth rate for normal responders undergoing ICSI "GnRH- antagonist" cycles.
Patients and Methods: a total 200 infertile women were included in this study, randomized and divided into two equal groups: Group (1): hCG trigger only group; included 100 women who received the hCG trigger alone. Group (II): dual trigger group; included 100 women, who received the dual trigger (GnRha & hCG). All participants were subjected to; full history taking, complete general, abdominal and pelvic examinations and full investigations to confirm criteria of the study.All participants were subjected to controlled ovarian hyper stimulation protocol starting on day 2-3 of the menstrual cycle with a daily administration of recombinant FSH intramuscularly for 5 days, Co administration of the GnRH-ant was initiated at day 6 stimulation and was continued until triggering day. Oocyte retrieval was undertaken guided by transvaginal ultrasonography 34–36 h later. Transfer of fresh embryos was done 3 days after oocyte retrieval. The number of transferred embryos was 1–2 depending on embryo quality and patient age. |
