Background: Polycystic Ovary Syndrome (PCOS) is one of the most common causes of an-ovulatory, 4-7% of women, The aim of the study was to compare the extended letrozole regimen with the classical one in treatment of CC resistant PCO patients, Subjects and Methods: 60 infertile, PCO and CC resistant women were divided randomly into 2 groups, group I, (short letrozole therapy) received 2.5mg twice daily from 2nd day of cycle for 5 days and repeated for 3 cycles (classical regimen) and group II, (long letrozole therapy) treated by 2.5mg once daily from 2nd day of cycle for 10 days and repeated for 3 cycles (extended regimen). Follicular growth and endometrial thickness monitoring, in all patients was performed regulary by trans-vaginal ultrasound. On day 10 of the cycles. HCG injection (5,000 IU IM) was given when at least one follicle measured ≥ 18mm followed by timed intercourse. |
