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Prof. Ehsan Mahmoud Ahmed Mahmoud Fahmy :: Publications: |
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| Title: | Effect OF CARBAMAZEPINE AND PHENYTOIN ON CLONAZEPAM AND 7 AMINO CLONAZEPAM SERUM LEVEL |
| Authors: | M.Sayed Adel Halim, Khadiga M Ragheb, Laila El Mossely, Ehsane M. Fahmy |
| Year: | 1992 |
| Keywords: | epilepsy,clonazepam,carbamazepine, phenytoin |
| Journal: | The New Egyptian Journal of Medicine |
| Volume: | 7 |
| Issue: | 6 |
| Pages: | 1437-1441 |
| Publisher: | Not Available |
| Local/International: | Local |
| Paper Link: | Not Available |
| Full paper | Ehsan Mahmoud Ahmed Mahmoud Fahmy_december 1992.pdf |
| Supplementary materials | Not Available |
| Abstract: |
The effect of carbamezepine and phenytoin on the serum level of clonazepam and its major metabolite 7- aminoclonazepam was studied in epileptic patients chronically treated with combination of those drugs. Carbamazepine produced consistent but insignificant lowering of the clonazepam serum level which averaged 20% wiithout noticeable effect on the 7- aminoclonazepam. Phenytoin however produced significant reductions in clonazepam with slight lowering of 7- aminoclonazepam.The present finding indicates that phenytoin and to less extent carbamezapine lower the clonazepam serum level. the finding also suggests that the effect may be due to enhanced metabolism of clonazepam via transformation into 7- aminoclonazepam |
