Background
Glaucoma is a progressive optic neuropathy, which can result in irreversible
blindness. The main pathologic change in glaucoma is retinal ganglion cell loss.
The macula has the greatest density of retinal ganglion cells (∼50%).
The advent of spectral domain-optical coherence tomography (OCT) technology
has allowed advanced macular imaging protocols to play an important role in the
diagnosis and monitoring of glaucoma. The ganglion cell analysis is obtained by the
Cirrus HD-OCT system segments and measures the thickness of the ganglion
cell? inner plexiform layer, thereby potentially increasing its diagnostic accuracy
compared with conventional peripapillary retinal nerve fiber layer (RNFL) thickness
measurement.
Patients and methods
The study was done on 40 eyes of 40 patients, and patients were divided into two
groups:
Group 1 included 20 adult patients more than 18 years who were diagnosed with
primary open-angle glaucoma. Group 2 included 20 normal controls. One eye of
each individual was prospectively enrolled.
The OCT was done using 3D-OCT 2000 (Topcon) to evaluate the following: RNFL
parameters (average total thickness, superior average thickness, and inferior
average thickness) and ganglion cell complex (GCC) parameters (total average
thickness, superior average thickness, and inferior average thickness).
Result
There was a positive statistically significant correlation of high probability between
the two groups regarding RNFL thickness (P |
