Background and aim: Diabetic retinopathy (DR) and maculopathy are major tragedies
in ophthalmology. Lipoprotein (Lp) (a) is a pro-atherogenic and pro-thrombotic risk
factor. It has an antifibrinolytic effect with increasing risk of clotting and blood vessel
occlusion. Elevated Lp(a) concentrations can also damage the microcirculation by its
oxidative effect. The aim of this study was to investigate the relationship between serum
level of Lp(a) and developing maculopathy in diabetic patients by measuring central
macular thickness (CMT) using Optical Coherence Tomography (OCT).
Methods: Case-control study included one case group of 40 eye of 20 diabetic patients
and one control group of 40 eyes of 20 non-diabetic age and gender matched controls. All
the participants were subjected to full ophthalmological examination with best corrected
visual acuity (BCVA) testing, Body Mass Index (BMI) calculation, glycosylated
hemoglobin (HbA1c), serum Lp (a) and CMT measurement by 3D OCT.
Results: There was no significant difference between the two groups regarding age or
gender. Cases group had significantly higher BMI, HbA1c, LP (a) and CMT than control
group (p |
