Bisphenol- A (BPA), an estrogenic compound, is used in manufacture of polycarbonate plastics and epoxy resins. Sesame oil is a potent antioxidant dietary source for human health.
Aim of the work: The present study is conducted to estimate the protective effects of sesame oil (SO) against bisphenol-A (BPA) induced Cardiotoxicity.
Material and methods: Thirty two adult rats were divided into 4 equal groups eight rat for each; Control group, 2 Treated group, one group received BPA ( 25 mg/kg b. wt.) orally 5 times/weak for 4 weeks and the other group rats received (50 mg/kg b. wt.) orally 5 times /weak for 4 weeks. Protected group rats received high dose of BPA (50 mg/kg b. wt.) orally 5 times /weak for 4 weeks plus sesame oil orally at a dose 10mL/kg b. wt. orally daily for 4 weeks. After the end of treatments. Blood samples were collected for biochemical assessment of the enzymes. The rats were sacrificed and the heart of each sacrificed animal was subjected to histopathological examination by H&E, Masson's and iNos stain.Results: Administration of high dose BPA (50mg/kg b wt) significantly increased the weight of rats, several histopathological alterations in cardiac tissue and elevation in MDA , CK-MB and GST and reduction of GSH and catalase when compared to the control. Low dose BPA (25mg/kg b wt ) produced mild histoapatholgical effect on the heart , On the contrary, oral gavages of sesame oil with BPA was effective in the reduction of weight, amelioration of histopathological alterations, and in the reduction of the MDA , CK-MB and GST levels and elevation of GSH and catalase activity when compared to high dose BPA's treated rats.
Conclusion: The present study provided clear evidence that sesame oil possesses a promising protective activity against the cardiotoxic effects of bisphenol
|
