Background:Endometrial carcinoma (EC) isa common gynecological malignancy, yet the mechanisms that lead to tumor development and progression are still not fully known. Objectives : We aimed to evaluate immunohistochemical (IHC) expression of MMP14, β1 integrin &YAP1 in EC type I and its relation to clinic-pathological parameters. Subjects and Methods:IHC expression of MMP14,β1- integrin&YAP1in 52 cases of ECtype I were studied.The association of these markers with each other as well as withclinic-pathological parameterswere evaluated.Results: Positive membranous and cytoplasmic IHC expression of MMP14 was detected in 36 (69.2%)of studied EC cases. Comparison of MMP14 IHC expression with the clinic-pathological data revealed higher expression of MMP 14 in high grades EC (II & III) and higher stages (II& III), compared to lower grades and stages but did not reach significant difference (P=0.077,P=0.925 respectively).No significant statistical difference with other variables (P>0.05for all). Cytoplasmic localization of β1 integrin was detected in 33(63.5%) of studied EC cases. Significant statistical difference with grade, depth of invasion (p0.05 for all).Nuclear IHC expression of YAP1 was detected in 34(65.4%) of studied EC cases. There issignificant statistical difference with grade&depth of invasion (p=0.001 for both), mean tumor size (P=0.033), LVI (p |
