Background: Chronic kidney disease (CKD) is characterized by the retention of toxins that contribute to the associated morbidity and mortality. The heterogeneity of uremic toxins with respect to their molecular weight and protein binding may affect their removal by hemodialysis (HD).
Objective: The aim of our work is to determine the serum level of ß2-microglobulin (ß2-m) in patients with CKD on regular hemodialysis and its relation to dialysis-related amyloidosis (DRA) manifestatins and the factors affecting it.
Methods: This is cross-sectional cross-over, hospital based study was conducted on thirty cases, twenty cases from the pediatric nephrology department in Benha University Hospital & ten cases from Menouf Hospital. All patients with end-stage renal disease (ESRD) who were on maintenance HD for more than three months were included in the study. Demographic data were collected and details of dialysis (type of dialyzers, dialysate bath, membrane used) & frequency for attendance of dialysis session were recorded. Blood samples were drawn from all patients for hematological (hemoglobin, hematocrit), biochemical (urea, creatinine, albumin) and ß2-m level measurement. Then the cases were be further subdivided into two groups, (group IA 16 patients were switched to high flux HD for 6 months & group IB 14 patients continue on low flux HD). Also twenty patients on HD with ultrapure water & ten patients on pure water HD. 15 age & sex matched apparently healthy children as control.
Results: The mean serum level of ß2-m levels was significantly elevated in the study patients compared to the control groug with a mean (52.9± 24. mg/L) & (1.2±2.9mg/L) respectively. Post-high flux ß2-m level was significantly lower than pre-high flux levels with P value |
