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Dr. Eman Rateb Abd Elmnoaem :: Publications:

Title:
Predictive and diagnostic value of serum intestinal fatty acid binding protein in neonatal necrotizing enterocolitis (case series)
Authors: Omima M. Abdel-Haie , Eman G. Behiry , Eman R. Abd Almonaem, Enas S. Ahmad, Effat H. Assar
Year: 2017
Keywords: Not Available
Journal: annals medicine and surgery
Volume: 21
Issue: Not Available
Pages: 9:13
Publisher: Not Available
Local/International: International
Paper Link:
Full paper Eman Rateb Abd Elmnoaem_Annals of Medicine and Surgery.pdf
Supplementary materials Not Available
Abstract:

Objectives: In this study, we aimed to investigate the value of serum intestinal fatty acid binding protein (I-FABP) in early diagnosis and predicting the severity of Necrotizing enterocolitis (NEC). Methods: This prospective study was performed on 160 preterm neonates ageing less than 35 weeks and weighting less than 2000 gm selected from the Neonatal Intensive Care Units (NICUs) of the Pediatric Department at Benha University hospital and Benha children hospital to evaluate which of them will develop NEC, after follow-up these neonates were divided into two groups: Group one compromised eighteen preterm neonates with symptoms and signs of NEC. Group two compromised ten preterm neonates as a control group. All participants were subjected to full clinical examination, abdominal X-ray and serum I-FABP. Results: The 1st values of IFABP taken at birth showed that mean serum IFABP concentrations of the study group were higher than that of the control group. The 2nd values of serum IFABP taken at the start of feeding showed that mean IFABP concentrations of the study group were higher in comparison with IFABP at birth. In the 3rd values of serum, IFABP taken at the time of diagnosing NEC showed that mean serum IFABP concentrations of the study group were higher than the control group. In the 4th values of serum, IFABP taken one week after diagnosing NEC showed that the mean serum IFABP concentrations of the study group became significantly decreased in comparison with IFABP at the time of diagnosis in stage 1 and 2. Conclusions: Serial measurements of serum I-FABP levels may be a useful marker for early diagnosis and prediction of disease severity in NEC. © 2017 The Author(s). Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. This is an open access article under the CC BY-NC-ND license

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