Neonatal sepsis displayed the different symptoms in comparison with that of children or
adults sepsis because of the infant’s immature immune system. It’s not clear whether these mi RNA biomarkers can
be used as fingerprints to evaluate the prognosis of neonatal sepsis, and there have been few studies on the
evaluation of mi RNA level in infant sepsis, thus it is necessary to confirm whether these mi RNAs can function as
biomarkers in neonatal sepsis patients. The aim of this work was to investigate the possible value of circulating
micro RNAs 16/ 34 a in the diagnosis and prognosis of neonatal sepsis. Methods: This study was a case control
study, which done on 100 neonates (80 cases and 20 neonates with age and sex matched to the first group and
apparently healthy, considered as a control group). Cases group are subdivided into 2 groups culture +ve group (40
cases) and culture –ve group (40 cases). This study was done at full terms attending Neonatal Intensive care Unit
(NICU) in Benha University Hospitals. All subjects were subjected to history, clinical examination and laboratory
investigation including estimation of miR-16 and 34 a. Results: There was a significant association between
maternal risk factors as PROM and UTI and sepsis (P |
