AUTHOR COPY
Journal of Neonatal-Perinatal Medicine 14 (2021) 511–517
DOI:10.3233/NPM-200604
IOS Press
511
Original Research
Relation of asymmetric dimethylarginine
with pulmonary morbidities in neonatal
respiratory distress syndrome
Neveen Tawfik Abeda, Omima Mohamed Abdel Haiea, Amira Ibrahim Mansourb,∗
and Eman Rateb Abd Almonaema
aDepartment of Pediatrics, Benha Faculty of Medicine, Benha University, Egypt
bDepartment of Clinical and Chemical Pathology, Benha Faculty of Medicine, Benha University, Egypt
Abstract.
BACKGROUND: Asymmetric Dimethyl Arginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS) is
important in different diseases characterized by decreased nitric oxide (NO) availability. We aimed to assess the serumADMA
level in preterm infants suffering from respiratory distress syndrome (RDS) and its relationship with pulmonary outcomes.
METHODS: This prospective study included 50 preterm neonates suffering from RDS aging≤32 weeks and weighing≤
1500 gm. Serum ADMA levels were estimated in the 1st and 28th day of life by ELISA, and its correlation with
surfactant requirement, duration of ventilation, and development of BPD was assessed.
RESULTS: Fifty preterm infants with RDS were included, 30 infants were treated with surfactant within 12 hours after
birth, the 1stday ADMA level was higher significantly in infants who required surfactant treatment than infants without
surfactant treatment, At 36 weeks postmenstrual age, 16 infants were diagnosed with BPD, the 28th day ADMA level was
significantly higher in infants with BPD than others without BPD. 1st-day ADMA level was significantly correlated with
days on mechanical ventilation but there were no significant correlations between 1st day ADMA and days on CPAP and
days on supplemental O2.
CONCLUSION:Elevated serumADMAlevel in preterm neonates withRDSestimated in the 1st and 28th day of life is a good
predictor for pulmonary morbidities such as surfactant requirement, duration of mechanical ventilation, and development of
BPD.
Keywords: ADMA, RDS, BPD, preterm |
