Background: Toxoplasmosis is an infectious disease caused by
Toxoplasma gondii. The Toxoplasma gondii strain has an impact on the
severity of toxoplasmosis. The severity of infection is mostly
determined by the host's immune response, so, infections in
immunocompetent people typically asymptomatic. Infection can induce
neurological, ocular, and systemic disorders in immunocompromised
patients. Nanomedicine developments appear promising, allowing
toxoplasmosis to be treated with nanotechnology. Aim:The aim of the
present work was to assess the effect of ciprofloxacin and ciprofloxacin
loaded on silver nanoparticles on murine acute toxoplasmosis.
Materials and methods: Sixty Mice were used in this study divided
into 7 groups. Group I:Non Infected non-treated mice (5mice), group
II: Infected with acute strain (RH) non-treated mice (10 mice), group
III: Infected mice treated with Spiramycin 100mg/kg (10 mice), group
IV: Infected mice treated with ciprofloxacin 100mg/kg.(10 mice),
group V: Infected mice treated with ciprofloxacin loaded silver
nanoparticles 100mg/kg.(10 mice), group VI: Infected mice treated
with silver nanoparticles (10 mice) and group VII: Non infected
treated with silver nanoparticles(5mice). Effect of treatment was
assessed by counting the number of tachyzoites in peritoneal fluid,
survival rate and histopathological assessment of liver. Results:Ciprofloxacin treated group showed
significant reduction in tachyzoite count in peritoneal fluid, induced morphological alteration in
shape of tachyzoites and improved histopathological picture in liver tissue but didn’t significantly
improve survival rate in infected mice. The effect of Ciprofloxacin was augmented after loading it
a
Department of medical
parasitology, Benha faculty of
medicine, Benha University
Egypt.
b
Department of Epidemiology
and Zoonotic diseases,
National Research centre,
Egypt.
Correspondence to: Fayza
A. Ahmed, Department of
medical parasitology, Benha
faculty of medicine, Benha
University, Egypt
Email:
drfayza88@yahoo.com
Received: 31 January 2022
Accepted: 7 November 2022
Print ISSN 1110-208X
Online ISSN 2357-0016
Benha medical journal, vol. 39, issue 3, 2022
942
on silver nanoparticles. Conclusion:Ciprofloxacin proved its effectiveness against experimental
acute toxoplasmosis and its effect was augmented after loading it on silver nanoparticles. |
