Background:-. Peripheral insulin resistance is present in obese patients
primarily due to the marked down regulation of the insulin receptors. Obesity
is associated with elevated levels of chemerin that might influence
dysregulation of glucose metabolism. Omentin-1 (Intelectin-1) is a newly
identified protein that is highly and selectively expressed in visceral adipose
tissue. Controversy has arisen concerning the regulatory mechanisms that
modulate chemerin and omentin-1 expression and function, namely obesity,
chronic inflammation, insulin resistance, or oxidative stress.
Objectives:- The aim of this work is to estimate the serum levels of
chemerin and omentin 1 in obese patients with type 2 diabetes mellitus and
their correlation to disease progress and activity.
Subjects and methods:- This prospective study was conducted on 80
individuals where 60 subjects were complaining of type 2 diabetes mellitus
and 20 apparently healthy subjects serving as the control group. Individuals
were subjected to full history taking, thorough clinical examination,
anthropometric measurements, routine and specific laboratory investigations
including glycated Hb, fasting insulin level, HOMA-IR, chemerin and
omentin-1 serum levels.
Results:- We found that there were statistically high significant differences
between the studied groups regarding anthropometric measurements, DM
duration, fasting blood sugar, glycated hemoglobin, lipid profile, liver
function tests and chemerin and omentin, while there was significant
differences regarding insulin and HOMA. We found statistically high
significant positive correlations between chemerin and fasting blood sugar,
glycated hemoglobin, lipid profile , liver enzymes, HOMA -IR and body
mass index. There were statistically high significant negative correlations
between omentin and fasting blood sugar, glycated hemoglobin, lipid profile,
liver enzymes, HOMA -IR and body mass index, significant positive
correlations regarding duration and insulin.
Conclusion:- Chemerin levels were significantly increased in obese patients
and were related to insulin resistance. Omentin-1 levels were decreased in
morbid obesity (MO), were inversely associated with chronic inflammation
and dyslipidemia and the main modulating factors seemed to be
dyslipidemia, hyperglycemia and BMI. |
