Abstract:
Background: cancer is considered a stem cell disease. Many stem cell markers are recently well-known to have main roles in carcinogenesis and tumor progression. ALDH1A1 is a stem cell marker that thought to have a role in many cancers. This study aimed to evaluate the expression of ALDH1A1 in different molecular types of breast invasive duct carcinomas, and its relation to clinicopathological data
Material and Methods: This is a retrospective study carried upon 40 cases of invasive ductal carcinoma (NOS) of the breast. Cases were collected form archives of Early Cancer Detection Unit (ECDU), Benha Faculty of Medicine and pathology department, International Medical Center, between the years 2007-2013. Previously ER, PR, Her2/neu and Ki67 stained slides were re-evaluated for each case. Both tumoral and stromal expression of ALDH1A1 was also evaluated for each case.
Results: A significant positive correlation of ALDH1A1tumoral expression was observed in patients with age >55 years (p |
