This study was conducted on 15 balady sheep of 1-3 year age to throw light on the effect of parasitism (mixed infestation with fascioliasis and nematodiasis) on the immune response of sheep to PPR living attenuated cell culture vaccine. Leukogram of infested vaccinated sheep declared significant reduction in the total leukocytes and lymphocytes count and significant elevation in neutrophils and eosinophils.
Serum biochemical panel of infested vaccinated sheep revealed significant decrease in serum zinc, total protein, albumin, total globulin, gamma globulin, IgG, vitamins E and C and highly significant decrease in iron, copper, vitamins A and Beta-carotene in comparison to the values of these statements in control vaccinated non infested sheep.
Immune response of the vaccinated animals as concluded from serum neutralization test revealed that, the infested group were responded poorly to PPR vaccine where serum neutralization antibodies titer were 2, 4 and 4 at 2WPV, 2MPV and 3MPV, respectively, while the titer in control non infested sheep was 16, 64 and 64, respectively during the same periods.
So consideration is put before vaccination to investigate the vaccinated animal clinically and coprologically and the infested animals should be treated by efficient broad spectrum anthelmentics beside good management and supplementation of these animals before vaccination with such elements that have a role in the immunity and immune response to restore deficiency associated with parasitism and correction of their level to normality to obtain maximum protective immune response at the required optimum level and improve the outcome of vaccination programs
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