Hassan, H.Y.; Magda S EL-Sayed*; Selim, H.M.** and Hamoda, F.K***.
Dept.Of Medicine.Infectious diseases, Fac.Vet.Med.Minufiya and Alexandria* Universities
Dept.Of Animal Medicine. Fac.Vet.Med.Zag University ** and Benha Branch***
A total of twenty-one (21) baldly sheep (1-3 years old) belonged to private flock at EL-Banger area in Alexandria governorate. Fourteen of these sheep were suffering from depraved appetite, unthriftness, rough coat and pale mucous membrane. The rest seven sheep were clinically healthy served as control group. Sheep under investigation were exposed to thoroughly clinical examination and parasitiological analysis including fecal and blood examination. These animals were free from internal and external parasitism. All animals were vaccinated with inactivated FMD vaccine.
Biochemical results showed highly significant decrease in copper, iron and ceruloplasmin. Also, there were significant decrease of total protein, albumin and globulin. On the other hand, the result of hemogram showed highly significant decrease in both hemoglobin and red blood cells, while there were significant decrease in the total leukocytic count. The differential leukocytic count showed significant decrease in the lymphocyte and neutrophile. All these altered parameters retained nearly to normal within four weeks postreatment. The serological analysis showed highly significant decrease in the serum antibodies titer before and four weeks of copper treatment.
On conclusion, trace elements status especially copper plays an important role in the immune response of vaccinated animals. So that repair copper deficiency before vaccination essential to ensure immunity against infectious diseases.
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