The present research focuses on pharmacological effects of Jatropha curcas extracts on specific biochemical parameters in
streptozotocin (STZ)-induced diabetic rats as compared to glibenclamide antidiabetic drug. Diabetes mellitus (DM) was induced
using STZ (45 mg/kg b.w). J. curcas extracts were orally administered at a dose of 250 mg/kg/day and glibenclamide at a dose of
10 mg/kg/day for 30 days. Creatinine, urea, inflammatory biomarkers; C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α)
and interlukin-10 (IL-10) levels were measured in rats blood serum. Creatinine, urea, CRP and TNF-α levels were significantly
increased in diabetic rats with percentages of 100, 53.33, 136.45 and 78.45%, respectively. However, IL-10 level showed significant
decrease with percentage 39.36%. The results showed that all J. curcas extracts have a positive effect against creatinine, urea, CRP
and TNF-α high level besides, relieving kidney disorders associated with DM. J. curcas could be applied effectively to reduce renal complications paralleling to DM. |
