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Dr. Fathy Attia Ismaiel Abdelfattah :: Publications:

Title:
Effect of the Growth Promotant Mannan- Oligosaccharide on the Lipogram and Organ Function Profile in Hyperlipidemic Albino Rats
Authors: Abubakr M. El-Mahmoudy*1, Fathy A. Abdel-Fattah2, Afaf D. Abd El-Mageid3 and Ibtsam M. Gheith4
Year: 2014
Keywords: Phytomedicine, Hyperlipidemia, Mannanoligosaccharide, MOS, Prebiotic.
Journal: American Journal of Phytomedicine and Clinical Therapeutics
Volume: 2
Issue: 3
Pages: 334-347
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Fathy Attia Ismaiel Abdelfattah_3-2014- Bio MOS.pdf
Supplementary materials Not Available
Abstract:

This study aimed to investigate the effect of mannan-oligosaccharide (MOS) on the lipogram and selected organ functions in hyperlipidemic rats. Animals were subjected to different treatments for 60 days. Balanced basal diet was supplied to control rats; saturated high fat- and/or MOS-contained diets were supplied to tested rats. Sera were collected on escalating times and total lipids, cholesterol, triacylglycerols, HDL-C, LDL-C, VLDL-C, AST, ALT, urea and creatinine were evaluated. On the last day, rats were sacrificed and the kidneys, liver, heart with aorta were picked out for histopathology. The results of MOS-treated group revealed significant decrease in total lipids, cholesterol, LDL-C, VLDL-C, AST, ALT, urea and creatinine with significant increase in HDL-C. Histopathological findings in the tested organs have been ameliorated with MOS, comparing with those in hyperlipidemic rats. The obtained data may give MOS the potential of antihyperlipidemic activity for prophylaxis and treatment of hyperlipidemia and related diseases.

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