This study aimed to investigate the effect of mannan-oligosaccharide
(MOS) on the lipogram and selected organ functions in
hyperlipidemic rats. Animals were subjected to different treatments
for 60 days. Balanced basal diet was supplied to control rats;
saturated high fat- and/or MOS-contained diets were supplied to
tested rats. Sera were collected on escalating times and total lipids,
cholesterol, triacylglycerols, HDL-C, LDL-C, VLDL-C, AST, ALT,
urea and creatinine were evaluated. On the last day, rats were
sacrificed and the kidneys, liver, heart with aorta were picked out for
histopathology. The results of MOS-treated group revealed
significant decrease in total lipids, cholesterol, LDL-C, VLDL-C,
AST, ALT, urea and creatinine with significant increase in HDL-C.
Histopathological findings in the tested organs have been ameliorated
with MOS, comparing with those in hyperlipidemic rats. The
obtained data may give MOS the potential of antihyperlipidemic
activity for prophylaxis and treatment of hyperlipidemia and related
diseases. |
