Introduction: Paraoxonases are a group of different forms enzymes that consist of three non-similar isoforms,
PON1, PON2 and PON3, which are located near to each other on the long arm of chromosome7. This study aims
to investigate the association of a Q192R polymorphism of PON1 gene and statin response in patients with
ischemic heart disease with dyslipidemia.
Methods: The studied population included three hundred patients with coronary artery disease with dyslipidemia who were prescribed statins. Total lipid profile was measured in these patients both before and after
approximately 6 months of treatment. Q192R polymorphism of PON1 gene was assessed by real-time PCR.
Results: There were no significant differences in baseline lipid levels according to different genotypes in all
studied casesof Q192R (rs662) polymorphism. HDL-C goals were attained less often in patients with RR
homozygosity than in Q allele carriers. Analysis by univariate logistic regression confirmed that QQ/QR carriers
had an increased chance of attaining HDL-C goals.
Conclusion: This study shows that the Q192R polymorphism of PON1gene has important role in interindividual
variety in accomplishment of HDL-C goals in response to statins. |
