Background: The prognostic value of amino terminal pro-brain natriuretic peptide levels in patients with acute exacerbation of chronic obstructive pulmonary disease has not been fully established. Objectives: This work aimed to evaluate the prognostic value of amino terminal pro-brain natriuretic peptide levels in patients with acute exacerbation COPD who need ICU admission. Methods: This prospective observational study included 80 patients who were admitted in chest ICU at Benha university hospital from may 2020 to march 2021 due to acute exacerbation of chronic obstructive pulmonary disease . Demographic data, noninvasive mechanical ventilation application, need for invasive mechanical ventilation, amino terminal pro-brain natriuretic peptide level, duration of mechanical ventilation, intensive care unit and hospital stay, weaning success, and mortality rates were recorded. Results: A total of 80 patients (74 males and 6 females) were included in the study. The mean age of the participants was 69 (53-84) years, and the mean. The mean amino terminal pro-brain natriuretic peptide level was found to be lower in cases with noninvasive mechanical ventilation success than those with noninvasive mechanical ventilation failure (320.50 – 991.90). In addition, the mean amino terminal pro-brain natriuretic peptide level was significantly higher (1004.90 – 1188.30, p=0.001) in patients who needed invasive mechanical ventilation support than in patients who did not. The mortality rate was significantly higher in patients who had an increasing trend of amino terminal pro-brain natriuretic peptide levels during hospitalization in patients who were on IMV(12.5%,). Conclusion In cases of acute exacerbation of chronic obstructive pulmonary disease requiring mechanical ventilation, amino terminal pro-brain natriuretic peptide measurement and monitoring of its trend may be a valuable asset in predicting mortality, noninvasive mechanical ventilation, weaning success, and need for invasive mechanical ventilation. |
