Understand the mechanism by which bovine herpesvirus 1 (BoHV-1) and herpes simplex virus 1 (HSV-1) establish, maintain, and reactivate from latency. 1. Identify cellular factors that control life-long maintenance of latency. 2. Identify the mechanism by which stress regulates reactivation from latency. 3. Identify the mechanism by which viral genes regulate the latency-reactivation cycle in sensory neurons.