Background:-Sepsis is a common cause of morbidity and mortality among
neonates, and current biomarkers for diagnosis are not adequate. The
objective of the study was to assess the diagnostic and prognostic value of
presepsin.
Methods:-One hundred and twenty neonates were enrolled in the study; 80
cases and 40 controls. Presepsin and CRP levels were measured during 1st,
2nd& 6th days of admission for cases while were measured once for each
control.
Results:-Initial presepsin levels were significantly higher in group produced
neonatal sepsis than in the non-septic group. At a cut off value ≥ 0.722 µg/L,
Presepsin sensitivity for prediction of neonatal sepsis was 100 %, specificity
97.5%, positive predictive value (PPV) 98.7%, negative predictive value
(NPV) 100%, area under curve (AUC) 0.99 with high sensitive positive
correlation with sepsis (P value < 0.001). At a cut off value < 2.3 µg/L, Its
prognostic sensitivity was 75.9%, specificity 72.5%, PPV 61.1, NPV 84.1
and AUC 0.76.
Conclusion:-Presepsin sensitivity for early diagnosis of neonatal sepsis was
100 % with specificity 97.5%. Presepsin is an accurate biomarker for early
diagnosis of neonatal sepsis. It also provides a useful tool for prediction of
improving. |
