ABSTRACT
Background: Pancreatic cancer is a disease with an extremely poor prognosis. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is emerging as an important determinant of the malignant phenotype in a range of cancers, including pancreatic cancer. Therefore, the aim of this study was to evaluate the potential involvement of CEACAM6 in the development, invasion and metastasis of pancreatic cancer cells.
Patients & Methods: This prospective study included 7 cases of chronic pancreatitis and 25 cases of pancreatic duct adenocarcinoma, which were collected from General Surgery Department, Faculty of Medicine, Benha University and Egyptian National Cancer Institute (NCI), in the period 2010-2014. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) immunohistochemical staining and soluble CEACAM6 were estimated in all cases and the pattern of expression in tissue was analyzed.
Results: Eighty eight percent of pancreatic ductal adenocarcinoma cases were positive for CEACAM6, while only 14.3% of chronic pancreatitis were positive, which was statistically significant (p |
