Abstract
Measurement of 24 hour urine protein is one of the most important tests ordered in the investigation of renal diseases but there are many limitations to the accurate performance of this test. Objective: To compare between random single voided urine protein to creatinine ratio (UPCR) and 24 hour total urinary proteins in the evaluation of proteinuria.
Methods: Thirty patients from Pediatric Department, Benha University Hospital were included in this cross section study. Patients were divided into two groups according to urinary protein level. CBC, lipid profile, serum albumin, blood urea and creatinine were done to all cases.
Spot UPCR and 24 hour urine protein were measured. The correlation coefficient (r) between them was calculated in each group separately. Then both groups were merged together as one group for further correlation tests.
Results: There were non-significant differences between both groups regarding age, weight, height, gender, BMI, and CBC. Significant differences were found regarding serum lipids, albumin, 24 hour urinary proteins and UPCR (p < 0.001). In group I correlation coefficient "r" between spot urine protein to creatinine ratio and 24 hour urine protein was 0.957, in group II "r" was 0.989, in all patients as total "r" was 0.9832. The concordance correlation coefficient was 0.9258. Difference between areas under (ROC) curves had significance level (P = 0.978). The scatter diagram coefficient of determination was 0.9667. Bland-Altman limits of agreement were (+1.498:-0.222).Also, the inter-rater agreement Kappa indicating very good agreement between the two methods
Conclusion: Random single voided urine protein to creatinine ratio could be used as an alternative to 24 hour urine collection for protein at different levels of proteinuria.
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