| You are in:Home/Publications/Tea Polyphenol Liposomes Overcome Gastric Mucus to Treat Helicobacter Pylori Infection and Enhance the Intestinal Microenvironment | |
Ass. Lect. Hagar Shendy Eltokhy Bahlol :: Publications: |
|
| Title: | Tea Polyphenol Liposomes Overcome Gastric Mucus to Treat Helicobacter Pylori Infection and Enhance the Intestinal Microenvironment |
| Authors: | Guiyun Deng, Yang Wu, Zhiyong Song, Shuojun Li, Moqing Du, Jiamin Deng, Quan Xu, Liu Deng, Hagar Shendy Bahlol, Heyou Han |
| Year: | 2022 |
| Keywords: | Not Available |
| Journal: | ACS Applied Materials & Interfaces |
| Volume: | 14 |
| Issue: | 11 |
| Pages: | 13001-13012 |
| Publisher: | American Chemical Society |
| Local/International: | International |
| Paper Link: | |
| Full paper | Hagar Shendy Eltokhy Bahlol_Tea Polyphenol Liposomes Overcome Gastric Mucus to Treat Helicobacter Pylori Infection and Enhance the Intestinal Microenvironment.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Infection with Helicobacter pylori (Hp) is one of the leading causes of stomach cancer. The ability to treat Hp infection is hampered by a lack of stomach gastric acid environment. This work introduces a nanoliposome that can rapidly adjust the gastric acid environment to ensure a drug’s optimal efficacy. We introduce CaCO3@Fe–TP@EggPC nanoliposomes (CTE NLs) that are composed of Fe3+ and tea polyphenols (TPs) forming complexes on the surface of internal CaCO3 and then with lecithin producing a phospholipid bilayer on the polyphenols’ outer surface. Through the action of iron–TP chelate, the phospholipid layer can fuse with the bacterial membrane to eliminate Hp. Furthermore, CaCO3 can promptly consume the excessive gastric acid, ensuring an ideal operating environment for the chelate. TPs, on the other hand, can improve the inflammation and gut microbes in the body. The experimental results … |
