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Ass. Lect. Hanaa Mohamed Ali Abdelmonem Abostate :: Publications:

Title:
The significance of Aldehyde dehydrogenase 1A1 expression in colorectal carcinoma
Authors: Eman Mohamed Said Zedan Hanaa Mohamed Ali Abostate. Hala Adel Agina, Nashwa Mohamed Emara
Year: 2020
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: Local
Paper Link: Not Available
Full paper Hanaa Mohamed Ali Abdelmonem Abostate_7-Material and methods.pdf
Supplementary materials Not Available
Abstract:

Background: Colorectal carcinoma (CRC) is the third most common cancer in the world constituting about 10% of all cancers. ALDH1A1 has been used as a stem cell marker, and plays important functional roles in stem cells. Expression of ALDH1A1 by cancer stem cells (CSCs) has been demonstrated in multiple types of cancers. Aim: This work aimed to evaluate ALDH1A1 expression in colorectal adenocarcinoma and determine the relation between ALDH1A1 expression and different clinico-pathological variables. Material and method: This is a selected retrospective study included 50 different cases of colorectal adenocarcinoma. ALDH1A1 immunostaining was performed for all cases. Results: There was a highly significant statistical difference between ALDH1A1 expression in studied cases according to tumor site, lymph node metastasis and TNM stage (P value

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