Background: Globally, Gastric carcinoma (GC) is one of the
most common cancers and leading causes of cancer death. The
role of Ephrin type-B receptor 2 (EphB2) and Cell adhesion
molecule 4 (CADM4) in initiation or progression of cancers was
assessed in multiple studies. However, there is a debate about
their role in GC. Aim: To evaluate EphB2 and CADM4
immunohistochemical expression in GC and its precursor lesions
to assess their possible roles. Material and method: In this
retrospective study, EphB2 and CADM4 immunostaining was
performed for 50 selected cases of GC, 10 cases of chronic
gastritis, 6 cases of chronic gastritis with intestinal metaplasia
and 6 cases of gastric adenoma. Results: There was a highly
significant statistical difference between the study groups
regarding EphB2 and CADM4 expression (P= 0.002 and < 0.001
respectively). EphB2 expression was significantly associated
with increased depth of tumor invasion, lymph node metastasis,
distant metastasis and advanced stage (P= 0.006, 0.026, 0.016
and < 0.001 respectively). Loss of CADM4 expression was
significantly associated with certain histopathological subtypes,
high grade tumors, distant metastasis and advanced stage (P=
0.032, 0.015, 0.007 and 0.012 respectively). Low CADM4
expression was significantly associated with increased depth of
tumor invasion, distant metastasis and advanced stage (P= 0.027,
0.006 and 0.003 respectively). Conclusion: EphB2 and CADM4
may have a role in pathogenesis and progression of GC and may
work combined as useful prognostic markers and therapeutic
targets for GC patients |
