The aim of this work was to evaluate the efficacy and safety of intralesional injection of 5-fluorouracil and bleomycin in the treatment
of keloids and hypertrophic scars. One hundred and twenty patients were divided into the following groups: group IA was injected
intralesionally with 5-fluorouracil; group IB was injected intralesionally with a combination of triamcinolone acetonide and
5-fluorouracil; group II was injected intralesionally with bleomycin. Patients underwent follow up by photographing and Vancouver scar
scale system. There was a significant improvement in the Vancouver scar scale in group II compared to group I after treatment. There
was hyperpigmentation, pain and ulceration in all the studied groups. Pain was significantly decreased in group IB compared to that in
group IA, ulceration was significantly decreased in group II than in group I while pain after injection was increased in group II than in
group I. Relapse occurred in 12 patients of group IA, 14 patients of group IB and no relapse occurred in group II. So, intralesional
injection of bleomycin was more effective and better in remission than intralesional 5-fluorouracil injection in the treatment of keloids
and hypertrophic scars regardless of patient’s age, sex, disease duration or site of the lesion.
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CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
