ABSTRACT
Background and Objective: Mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) accelerate wound
healing. This study aimed to comparing the therapeutic role of BMSCs & PRP in skin burn healing.
Material and Methods: The study included forty albino rats, five rats were used to supply PRP and five rats were
considered as a control group. The other thirty rats were exposed to thermal injury to induce 2nd degree skin burn
then divided into three groups of ten rats each; the skin burned group including rats that received no further treatment,
BMSCs-treated group and PRP-treated group. Each group was subdivided into two equal subgroups and examined
on days 7 & 21 after the burn. Skin specimens of all groups were handled, processed to be stained with H&E,
Masson’s trichrome for histological examination and by VEGF, CD105 for immunohistochemical examination.
Results: Injection the burned skin with BMSCs or PRP caused re-epithelization of the epidermis, reduction of
inflammation, increased collagen fibers deposition and acceleration of angiogenesis. Visible epidermis and dermis
regeneration were more evident compared to the burned group. However, the improvement of histological findings
was remarkable in the BMSCs-treated group than in PRP treated one. Moreover, the main area percentage of collagen
fibers deposition and VEGF immunostaining were significantly increased in the BMSCs treated group in comparison
to PRP treated group.
Conclusion: BMSCs displayed better healing effect than PRP as evidenced by collagen fibers deposition and |
