NAFLD is frequently associated with the metabolic syndrome including obesity, type 2 diabetes mellitus, hypercholesterolemia and hypertension .Recently, there is accumulating evidence that renin-angiotensin- system (RAS) appears likely to play an important roles in various aspects of the metabolic syndrome.
The present study was designed to study the potential hepatoprotective effect of angiotensin converting enzyme inhibitor ACEI (captopril) and angiotensin II type I receptor blocker ARB ( irbesartan) on high fat diet (HFD) induced fatty liver in male rats. 40 male adult rats were used; rats were separated randomly into 4 groups, ten rats in each group. 1st group is control group was fed with standard chow diet and tap water. 2nd group received HFD (1% cholesterol and 10% coconut oil) via oral gavage for 8wks with no medication. 3rd group received HFD via oral gavage with oral administration of captopril100mg/kg/day for 8wks. 4thgroup received HFD via oral gavage with oral administration of Irbesartan 30mg/kg/day for 8wks. The obtained data in the current work revealed that HFD feeding resulted in significant increase (p |
