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Prof. Hanem Khater :: Publications:

Title:
Target Activity of Isaria tenuipes (Hypocreales: Clavicipitaceae) Fungal Strains against Dengue Vector Aedes aegypti (Linn.) and Its Non-Target Activity Against Aquatic Predators.
Authors: Karthi, S., Vasantha-Srinivasan, P., Ganesan, R., Ramasamy, V., Senthil-Nathan, S., Khater, H. F., Radhakrishnan N, Kim T, El-Sheikh M., and Krutmuang P
Year: 2020
Keywords: CYP450; arthropods; entomopathogen; gut-histology; mycotoxins; non-toxicity.
Journal: Journal of Fungi
Volume: 6
Issue: 4
Pages: 196-
Publisher: Not Available
Local/International: International
Paper Link:
Full paper Hanem Khater_Target Activity of Isaria tenuipes (Hypocreales Clavicipitaceae) Fungal Strains against Dengue Vector Aedes aegypti (Linn.) and Its Non-Target Activity Against Aquatic Predators.pdf
Supplementary materials Not Available
Abstract:

The present investigation aimed to determine the fungal toxicity of Isaria tenuipes (My-It) against the dengue mosquito vector Aedes aegypti L. and its non-target impact against the aquatic predator Toxorhynchitessplendens. Lethal concentrations (LC50 and LC90) of My-It were observed in 2.27 and 2.93 log ppm dosages, respectively. The sub-lethal dosage (My-It-1 × 104 conidia/mL) displayed a significant oviposition deterrence index and also blocked the fecundity rate of dengue mosquitos in a dose-dependent manner. The level of major detoxifying enzymes, such as carboxylesterase (α-and β-) and SOD, significantly declined in both third and fourth instar larvae at the maximum dosage of My-It 1 × 105 conidia/mL. However, the level of glutathione S-transferase (GST) and cytochrome P-450 (CYP450) declined steadily when the sub-lethal dosage was increased and attained maximum reduction in the enzyme level at the dosage of My-It (1 × 105 conidia/mL). Correspondingly, the gut-histology and photomicrography results made evident that My-It (1 × 105 conidia/mL) heavily damaged the internal gut cells and external physiology of the dengue larvae compared to the control. Moreover, the non-target toxicity against the beneficial predator revealed that My-It at the maximum dosage (1 × 1020 conidia/mL) was found to be less toxic with

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