Background and study aim. Non alcoholic fatty liver disease has an increasing prevelance worldwide. It is closely associated with metabolic syndrome. The aim of this study is to assess the association between non alcoholic fatty liver disease and serum level of Vitamin D. Subjects and Methods. This cross sectional study was conducted on95 subjects devided into 2 groups (1st group 45 patients with sonographically proven nonalcoholic fatty liver disease and 2nd group history taking, clinical examination, routine laboratory investigations, lipid profile, abdominal ultrasound and serum level of Vitamin D by ELISA. Results. Mean weight, Body mass index, and Waist circumference were significantly higher in patients with non alcoholic fatty liver disease than those without also they were significantly higher in patients with severe steatosis (P value 0.001, 0.000, 0.002 respectively). Incidence of Diabetes mellitus, Hypertension and Cardiovascular disease were significantly higher in patients with non alcoholic fatty liver disease than those without (P value 0.001,0.003 and 0.009 respectively).Serum level of Vitamin D was significantly lower in non alcoholic fatty liver disease patients than those without also their values were lower in overweight NAFLD patients than those with normal body mass index but with no significant difference. Conclusion: Serum level of Vitamin D was highly deficient in patients with non alcoholic fatty liver disease than those without and its level significantly decreased with increasing grades of non alcoholic fatty liver disease. |
