To investigate the relationship between clinical parameters of pre-eclampsia (PE) and serum
levels of Retinol binding protein4 (RBP4) and Placental growth factor (PlGF). Patients and Methods: The
study included 90 pregnant women categorized as Group I: Control group (n= 20), included pregnant
women who continued their pregnancy without development of PE manifestations, Group II: included
patients had Mild PE (n=56) and group III included patients had Severe PE (n=14). After clinical
evaluation and ultrasonographic examination, samples ofmaternal peripheral blood were obtained either at
time of diagnosis of PE in groups II and III or at time of delivery in control group for ELISA estimation of
serum RBP4 and PlGF. Results: PE patients had significantly lower serum PlGF, but significantly higher
serum RBP4 levels when compared to the corresponding levels of the control group. Serum levels of PlGF
showed negative correlation with systolic and diastolic blood pressures (SBP and DBP) and extent of
proteinuria, but showed positive significant correlation with birth weight, while serum levels of RBP4
showed positive significant correlation with DBP, extent of proteinuria and patients' body weight measures.
Conclusions: RBP4 and PlGF were associated with the development and severity of PE.
[Adel F. Al-Kholy, Mamdouh Z. Abadier, Ebrahem M. Rageh, Hany El-Kallaf.Serum levels of placental
growth factor and retinol-binding protein-4 in pregnancy-induced hypertensive women. Journal of
American Science 2010;6(12):448-455]. (ISSN: 1545-1003). |
