Background: Diabetes is associated with both micro- and
macrovascular complications. Aim of the study: The aim of the
present study is to evaluate the prophylactic effect of HCQ alone
and in combination with glimepiride and metformin on ISO induced
MI in type 2 diabetic rats. The present study included the parameters
blood glucose, plasma insulin, HOMA-IR index, lipid profile, AKT,
ECG changes and histopathology of the myocardium. Methods:
Rats were classified into: Group I: control normal group. Group II:
was not treated diabetic (diseased group). Group III: was treated
with HCQ. Group IV: was treated with glimepiride. Group V: was
treated with metformin. Group VI: was treated with HCQ +
glimepiride. Group VII: was treated with HCQ + metformin. treated
groups received drugs for 4 weeks. Results: Treated groups showed
significant improvement in all parameters and improvement of the
histopathology of the myocardium. A significant improvement in
the parameters was seen in the treated groups at the end of the 4th week. Conclusion: Our study
revealed that HCQ with glimepiride or with metformin produced more improvement in blood
glucose level, insulin, HOMA-IR, lipid profile, AKT, ECG changes, histopathology of the
myocardium. So, our drugs, mainly combined drugs may have a prophylactic effect against MI
in diabetic rats. this may be due to their glycemic control and improvement of dyslipidemia. |
